Preventing ovarian cancer by salpingectomy.
نویسنده
چکیده
An error was made in the text of the paper (p. 139, col. 1, under the subheading The Origins of High-Grade Ovarian Carcinoma). The sentence Further studies have confirmed that in situ serous tubal carcinomas are present in between 60% and 100% of preventive oophorectomy specimens from women with BRCA1 or BRCA2 mutations, but also that such disease is seen in the excised fallopian tubes of 30%–60% of women with high-grade serous carcinomas who do not carry BRCA1/2 mutations. should read Further studies have confirmed that in situ serous tubal carcinomas are present in approximately 8%–12% of preventive salpingo-oophorectomy specimens from women with BRCA1 or BRCA2 mutations, but also that such disease is seen in the excised fallopian tubes of 30%–60% of women with high-grade serous carcinomas who do not carry BRCA1/2 mutations.
منابع مشابه
Opportunistic salpingectomy at benign gynecological surgery for reducing ovarian cancer risk: a 10-year single centre experience from China and a literature review
Current evidences indicate that the fallopian tube plays a major role in the pathogenesis of epithelial ovarian cancer (EOC). Salpingectomy represents a novel and potentially effective risk-reducing option. In this study, there were 1822 patients diagnosed and treated for EOC or primary peritoneal cancer (PPC) at Department of Gynecologic Oncology, Tianjin Medical University Cancer Institute an...
متن کاملPublic perception of risk-reducing salpingectomy for preventing ovarian cancer
OBJECTIVE The fallopian tube is considered as the site of origin of serous ovarian cancer, and risk-reducing salpingectomy (RRS) has been proposed as a new and safe strategy for preventing ovarian cancer. However, little is known about the public perception of RRS. METHODS We performed a questionnaire survey of 100 healthy female volunteers in November 2014. Questionnaire for this survey incl...
متن کاملSalpingectomy as a means to reduce ovarian cancer risk.
Bilateral salpingo-oophorectomy (BSO) has become the standard-of-care for risk reduction in women at hereditary risk of ovarian cancer. Although this procedure significantly decreases both the incidence of and mortality from ovarian cancer, it affects quality of life, and the premature cessation of ovarian function may have long-term health hazards. Recent advances in our understanding of the m...
متن کاملSalpingectomy With Delayed Oophorectomy in BRCA1/2 Mutation Carriers: Estimating Ovarian Cancer Risk.
OBJECTIVE To estimate BRCA1/2 mutation carriers' cumulative ovarian cancer risks after risk-reducing salpingectomy at various ages with delayed oophorectomy several years later compared with risk-reducing salpingo-oophorectomy. METHODS A literature search was performed on cumulative ovarian cancer risks and effects of risk-reducing salpingo-oophorectomy and salpingectomy. Results were used in...
متن کاملRisk-reducing salpingectomy: Let us be opportunistic.
Because there is no screening test for ovarian cancer, effective prevention strategies may be the best way to reduce the mortality of this most lethal gynecologic malignancy. Increasing evidence supports the hypothesis that the fallopian tube is the site of origin for the vast majority of high-grade serous carcinomas. Our growing understanding of the pathogenesis of this disease offers a rare o...
متن کاملOvarian Cancer: The Fallopian Tube as the Site of Origin and Opportunities for Prevention
High-grade serous carcinoma (HGSC) is the most common and aggressive histotype of epithelial ovarian cancer (EOC), and it is the predominant histotype associated with hereditary breast and ovarian cancer syndrome (HBOC). Mutations in BRCA1 and BRCA2 are responsible for most of the known causes of HBOC, while mutations in mismatch repair genes and several genes of moderate penetrance are respons...
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ورودعنوان ژورنال:
- Current oncology
دوره 20 3 شماره
صفحات -
تاریخ انتشار 2013